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Coderre, J. A., Beverley, S. M., Schimke, R. T., Santi, D. V. (1983) Overproduction of a bifunctional thymidylate synthetase-dihydrofolate reductase and DNA amplification in methotrexate-resistant Leishmania tropica. Proceedings of the National Academy of Sciences, 80 (8) 2132-2136 doi:10.1073/pnas.80.8.2132

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Reference TypeJournal (article/letter/editorial)
TitleOverproduction of a bifunctional thymidylate synthetase-dihydrofolate reductase and DNA amplification in methotrexate-resistant Leishmania tropica.
JournalProceedings of the National Academy of Sciences
AuthorsCoderre, J. A.Author
Beverley, S. M.Author
Schimke, R. T.Author
Santi, D. V.Author
Year1983 (April 1)Volume80
Issue8
PublisherProceedings of the National Academy of Sciences
DOIdoi:10.1073/pnas.80.8.2132Search in ResearchGate
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Mindat Ref. ID1433503Long-form Identifiermindat:1:5:1433503:1
GUID0
Full ReferenceCoderre, J. A., Beverley, S. M., Schimke, R. T., Santi, D. V. (1983) Overproduction of a bifunctional thymidylate synthetase-dihydrofolate reductase and DNA amplification in methotrexate-resistant Leishmania tropica. Proceedings of the National Academy of Sciences, 80 (8) 2132-2136 doi:10.1073/pnas.80.8.2132
Plain TextCoderre, J. A., Beverley, S. M., Schimke, R. T., Santi, D. V. (1983) Overproduction of a bifunctional thymidylate synthetase-dihydrofolate reductase and DNA amplification in methotrexate-resistant Leishmania tropica. Proceedings of the National Academy of Sciences, 80 (8) 2132-2136 doi:10.1073/pnas.80.8.2132
In(1983, April) Proceedings of the National Academy of Sciences Vol. 80 (8) Proceedings of the National Academy of Sciences

See Also

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Garvey, E. P., Santi, D. V. (1985) Limited proteolysis of the bifunctional thymidylate synthase-dihydrofolate reductase from Leishmania tropica. Proceedings of the National Academy of Sciences, 82 (21) 7188-7192 doi:10.1073/pnas.82.21.7188
Grumont, R., Washtien, W. L., Caput, D., Santi, D. V. (1986) Bifunctional thymidylate synthase-dihydrofolate reductase from Leishmania tropica: sequence homology with the corresponding monofunctional proteins. Proceedings of the National Academy of Sciences, 83 (15) 5387-5391 doi:10.1073/pnas.83.15.5387
Johnston, R. N., Beverley, S. M., Schimke, R. T. (1983) Rapid spontaneous dihydrofolate reductase gene amplification shown by fluorescence-activated cell sorting. Proceedings of the National Academy of Sciences, 80 (12) 3711-3715 doi:10.1073/pnas.80.12.3711
Beverley, S. M., Ellenberger, T. E., Cordingley, J. S. (1986) Primary structure of the gene encoding the bifunctional dihydrofolate reductase-thymidylate synthase of Leishmania major. Proceedings of the National Academy of Sciences, 83 (8) 2584-2588 doi:10.1073/pnas.83.8.2584
Kaufman, R. J., Brown, P. C., Schimke, R. T. (1979) Amplified dihydrofolate reductase genes in unstably methotrexate-resistant cells are associated with double minute chromosomes. Proceedings of the National Academy of Sciences, 76 (11) 5669-5673 doi:10.1073/pnas.76.11.5669
Ferone, R., Roland, S. (1980) Dihydrofolate reductase: thymidylate synthase, a bifunctional polypeptide from Crithidia fasciculata. Proceedings of the National Academy of Sciences, 77 (10) 5802-5806 doi:10.1073/pnas.77.10.5802
Sirawaraporn, W., Sathitkul, T., Sirawaraporn, R., Yuthavong, Y., Santi, D. V. (1997) Antifolate-resistant mutants of Plasmodium falciparum dihydrofolate reductase. Proceedings of the National Academy of Sciences, 94 (4) 1124-1129 doi:10.1073/pnas.94.4.1124
Nunberg, J. H., Kaufman, R. J., Schimke, R. T., Urlaub, G., Chasin, L. A. (1978) Amplified dihydrofolate reductase genes are localized to a homogeneously staining region of a single chromosome in a methotrexate-resistant Chinese hamster ovary cell line. Proceedings of the National Academy of Sciences, 75 (11) 5553-5556 doi:10.1073/pnas.75.11.5553
Mariani, B. D., Slate, D. L., Schimke, R. T. (1981) S phase-specific synthesis of dihydrofolate reductase in Chinese hamster ovary cells. Proceedings of the National Academy of Sciences, 78 (8) 4985-4989 doi:10.1073/pnas.78.8.4985
Bello, A. R., Nare, B., Freedman, D., Hardy, L., Beverley, S. M. (1994) PTR1: a reductase mediating salvage of oxidized pteridines and methotrexate resistance in the protozoan parasite Leishmania major. Proceedings of the National Academy of Sciences, 91 (24) 11442-11446 doi:10.1073/pnas.91.24.11442
Rice, G. C., Hoy, C., Schimke, R. T. (1986) Transient hypoxia enhances the frequency of dihydrofolate reductase gene amplification in Chinese hamster ovary cells. Proceedings of the National Academy of Sciences, 83 (16) 5978-5982 doi:10.1073/pnas.83.16.5978
 
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