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Jones, Megan E., Büchler, Johanna, Dufor, Tom, Palomer, Ernest, Teo, Samuel, Martin-Flores, Nuria, Boroviak, Katharina, Metzakopian, Emmanouil, Gibb, Alasdair, Salinas, Patricia C. (2023) A genetic variant of the Wnt receptor LRP6 accelerates synapse degeneration during aging and in Alzheimer’s disease. Science Advances, 9 (2) doi:10.1126/sciadv.abo7421

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Reference TypeJournal (article/letter/editorial)
TitleA genetic variant of the Wnt receptor LRP6 accelerates synapse degeneration during aging and in Alzheimer’s disease
JournalScience Advances
AuthorsJones, Megan E.Author
Büchler, JohannaAuthor
Dufor, TomAuthor
Palomer, ErnestAuthor
Teo, SamuelAuthor
Martin-Flores, NuriaAuthor
Boroviak, KatharinaAuthor
Metzakopian, EmmanouilAuthor
Gibb, AlasdairAuthor
Salinas, Patricia C.Author
Year2023 (January 13)Volume9
Issue2
PublisherAmerican Association for the Advancement of Science (AAAS)
DOIdoi:10.1126/sciadv.abo7421Search in ResearchGate
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Mindat Ref. ID15663644Long-form Identifiermindat:1:5:15663644:7
GUID0
Full ReferenceJones, Megan E., Büchler, Johanna, Dufor, Tom, Palomer, Ernest, Teo, Samuel, Martin-Flores, Nuria, Boroviak, Katharina, Metzakopian, Emmanouil, Gibb, Alasdair, Salinas, Patricia C. (2023) A genetic variant of the Wnt receptor LRP6 accelerates synapse degeneration during aging and in Alzheimer’s disease. Science Advances, 9 (2) doi:10.1126/sciadv.abo7421
Plain TextJones, Megan E., Büchler, Johanna, Dufor, Tom, Palomer, Ernest, Teo, Samuel, Martin-Flores, Nuria, Boroviak, Katharina, Metzakopian, Emmanouil, Gibb, Alasdair, Salinas, Patricia C. (2023) A genetic variant of the Wnt receptor LRP6 accelerates synapse degeneration during aging and in Alzheimer’s disease. Science Advances, 9 (2) doi:10.1126/sciadv.abo7421
In(2023, January) Science Advances Vol. 9 (2) American Association for the Advancement of Science (AAAS)

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Marzo, Aude, Galli, Soledad, Lopes, Douglas, McLeod, Faye, Podpolny, Marina, Segovia-Roldan, Margarita, Ciani, Lorenza, Purro, Silvia, Cacucci, Francesca, Gibb, Alasdair, Salinas, Patricia C. (2016) Reversal of Synapse Degeneration by Restoring Wnt Signaling in the Adult Hippocampus. Current Biology, 26 (19). 2551-2561 doi:10.1016/j.cub.2016.07.024
Galli, Soledad, Lopes, Douglas M., Ammari, Rachida, Kopra, Jaakko, Millar, Sarah E., Gibb, Alasdair, Salinas, Patricia C. (2014) Deficient Wnt signalling triggers striatal synaptic degeneration and impaired motor behaviour in adult mice. Nature Communications, 5. doi:10.1038/ncomms5992
Ciani, Lorenza, Marzo, Aude, Boyle, Kieran, Stamatakou, Eleanna, Lopes, Douglas M., Anane, Derek, McLeod, Faye, Rosso, Silvana B., Gibb, Alasdair, Salinas, Patricia C. (2015) Wnt signalling tunes neurotransmitter release by directly targeting Synaptotagmin-1. Nature Communications, 6. doi:10.1038/ncomms9302
Jolly, Sarah, Lang, Verena, Koelzer, Viktor Hendrik, Sala Frigerio, Carlo, Magno, Lorenza, Salinas, Patricia C., Whiting, Paul, Palomer, Ernest (2019) Single-Cell Quantification of mRNA Expression in The Human Brain. Scientific Reports, 9. doi:10.1038/s41598-019-48787-w
Bilic, J., Huang, Y.-L., Davidson, G., Zimmermann, T., Cruciat, C.-M., Bienz, M., Niehrs, C. (2007) Wnt Induces LRP6 Signalosomes and Promotes Dishevelled-Dependent LRP6 Phosphorylation. Science, 316 (5831). 1619-1622 doi:10.1126/science.1137065
Petshow, Samuel, Coblentz, Azariah, Hamilton, Andrew M., Sarkar, Dipannita, Anisimova, Margarita, Flores, Juan C., Zito, Karen (2025) Activity-dependent regulation of Cdc42 by Ephexin5 drives synapse growth and stabilization. Science Advances, 11 (13). doi:10.1126/sciadv.adp5782
Salinas, Patricia C. (2003) Backchat at the synapse. Nature, 425 (6957). 464-467 doi:10.1038/425464a
Balmorez, Timothy, Sakazaki, Amy, Murakami, Shin (2023) Genetic Networks of Alzheimer’s Disease, Aging, and Longevity in Humans. International Journal of Molecular Sciences, 24 (6) 5178 doi:10.3390/ijms24065178
Salinas, Patricia C (2003) Synaptogenesis: Wnt and TGF-β Take Centre Stage. Current Biology, 13 (2). doi:10.1016/s0960-9822(02)01429-x
Strauss, E. (2002) AGING RESEARCH: Cancer-Stalling System Accelerates Aging. Science, 295 (5552). 28-29 doi:10.1126/science.295.5552.28
Franzmeier, Nicolai, Dewenter, Anna, Frontzkowski, Lukas, Dichgans, Martin, Rubinski, Anna, Neitzel, Julia, Smith, Ruben, Strandberg, Olof, Ossenkoppele, Rik, Buerger, Katharina, Duering, Marco, Hansson, Oskar, Ewers, Michael (2020) Patient-centered connectivity-based prediction of tau pathology spread in Alzheimer’s disease. Science Advances, 6 (48). doi:10.1126/sciadv.abd1327
 
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