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Kulic, L., Walter, J., Multhaup, G., Teplow, D. B., Baumeister, R., Romig, H., Capell, A., Steiner, H., Haass, C. (2000) Separation of presenilin function in amyloid beta -peptide generation and endoproteolysis of Notch. Proceedings of the National Academy of Sciences, 97 (11) 5913-5918 doi:10.1073/pnas.100049897

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Reference TypeJournal (article/letter/editorial)
TitleSeparation of presenilin function in amyloid beta -peptide generation and endoproteolysis of Notch
JournalProceedings of the National Academy of Sciences
AuthorsKulic, L.Author
Walter, J.Author
Multhaup, G.Author
Teplow, D. B.Author
Baumeister, R.Author
Romig, H.Author
Capell, A.Author
Steiner, H.Author
Haass, C.Author
Year2000 (May 23)Volume97
Issue11
PublisherProceedings of the National Academy of Sciences
DOIdoi:10.1073/pnas.100049897Search in ResearchGate
Generate Citation Formats
Mindat Ref. ID1640241Long-form Identifiermindat:1:5:1640241:6
GUID0
Full ReferenceKulic, L., Walter, J., Multhaup, G., Teplow, D. B., Baumeister, R., Romig, H., Capell, A., Steiner, H., Haass, C. (2000) Separation of presenilin function in amyloid beta -peptide generation and endoproteolysis of Notch. Proceedings of the National Academy of Sciences, 97 (11) 5913-5918 doi:10.1073/pnas.100049897
Plain TextKulic, L., Walter, J., Multhaup, G., Teplow, D. B., Baumeister, R., Romig, H., Capell, A., Steiner, H., Haass, C. (2000) Separation of presenilin function in amyloid beta -peptide generation and endoproteolysis of Notch. Proceedings of the National Academy of Sciences, 97 (11) 5913-5918 doi:10.1073/pnas.100049897
In(2000, May) Proceedings of the National Academy of Sciences Vol. 97 (11) Proceedings of the National Academy of Sciences

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Haass, C., Koo, E. H., Teplow, D. B., Selkoe, D. J. (1994) Polarized secretion of beta-amyloid precursor protein and amyloid beta-peptide in MDCK cells. Proceedings of the National Academy of Sciences, 91 (4) 1564-1568 doi:10.1073/pnas.91.4.1564
Moehlmann, T., Winkler, E., Xia, X., Edbauer, D., Murrell, J., Capell, A., Kaether, C., Zheng, H., Ghetti, B., Haass, C., Steiner, H. (2002) Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on A 42 production. Proceedings of the National Academy of Sciences, 99 (12) 8025-8030 doi:10.1073/pnas.112686799
Edbauer, D., Winkler, E., Haass, C., Steiner, H. (2002) Presenilin and nicastrin regulate each other and determine amyloid  -peptide production via complex formation. Proceedings of the National Academy of Sciences, 99 (13) 8666-8671 doi:10.1073/pnas.132277899
Walter, J., Grunberg, J., Capell, A., Pesold, B., Schindzielorz, A., Citron, M., Mendla, K., George-Hyslop, P. S., Multhaup, G., Selkoe, D. J., Haass, C. (1997) Proteolytic processing of the Alzheimer disease-associated presenilin-1 generates an in vivo substrate for protein kinase C. Proceedings of the National Academy of Sciences, 94 (10) 5349-5354 doi:10.1073/pnas.94.10.5349
Xia, W., Ray, W. J., Ostaszewski, B. L., Rahmati, T., Kimberly, W. T., Wolfe, M. S., Zhang, J., Goate, A. M., Selkoe, D. J. (2000) Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid beta -protein generation. Proceedings of the National Academy of Sciences, 97 (16) 9299-9304 doi:10.1073/pnas.97.16.9299
Tomita, T., Maruyama, K., Saido, T. C., Kume, H., Shinozaki, K., Tokuhiro, S., Capell, A., Walter, J., Grunberg, J., Haass, C., Iwatsubo, T., Obata, K. (1997) The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid   protein ending at the 42nd (or 43rd) residue. Proceedings of the National Academy of Sciences, 94 (5) 2025-2030 doi:10.1073/pnas.94.5.2025
Farzan, M., Schnitzler, C. E., Vasilieva, N., Leung, D., Choe, H. (2000) BACE2, a beta -secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein. Proceedings of the National Academy of Sciences, 97 (17) 9712-9717 doi:10.1073/pnas.160115697
Richter, L., Munter, L.-M., Ness, J., Hildebrand, P. W., Dasari, M., Unterreitmeier, S., Bulic, B., Beyermann, M., Gust, R., Reif, B., Weggen, S., Langosch, D., Multhaup, G. (2010) Amyloid beta 42 peptide (A 42)-lowering compounds directly bind to A  and interfere with amyloid precursor protein (APP) transmembrane dimerization. Proceedings of the National Academy of Sciences, 107 (33) 14597-14602 doi:10.1073/pnas.1003026107
Walter, J., Schindzielorz, A., Grunberg, J., Haass, C. (1999) Phosphorylation of presenilin-2 regulates its cleavage by caspases and retards progression of apoptosis. Proceedings of the National Academy of Sciences, 96 (4) 1391-1396 doi:10.1073/pnas.96.4.1391
Hung, A. Y., Koo, E. H., Haass, C., Selkoe, D. J. (1992) Increased expression of beta-amyloid precursor protein during neuronal differentiation is not accompanied by secretory cleavage. Proceedings of the National Academy of Sciences, 89 (20) 9439-9443 doi:10.1073/pnas.89.20.9439
Gouras, G. K., Xu, H., Gross, R. S., Greenfield, J. P., Hai, B., Wang, R., Greengard, P. (2000) Testosterone reduces neuronal secretion of Alzheimer's beta -amyloid peptides. Proceedings of the National Academy of Sciences, 97 (3) 1202-1205 doi:10.1073/pnas.97.3.1202
 
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